TSEN2 Antibody

Datasheet

Code	CSB-PA850858DSR1HU
Size	US$166
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Image	Western blot All lanes: TSEN2 antibody at 5μg/ml + 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 54, 52, 50, 48, 46 kDa Observed band size: 54 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TSEN2 Polyclonal antibody

Uniprot No.

Q8NCE0

Target Names

TSEN2

Alternative Names

HsSen2 antibody; MGC2776 antibody; MGC4440 antibody; SEN2 antibody; SEN2_HUMAN antibody; SEN2L antibody; tRNA intron endonuclease Sen2 antibody; tRNA splicing endonuclease 2 homolog (SEN2; S. cerevisiae) antibody; tRNA splicing endonuclease subunit Sen2 antibody; tRNA-intron endonuclease sen2 antibody; tRNA-splicing endonuclease subunit Sen2 antibody; TSEN 2 antibody; TSEN2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Involvement in disease

Pontocerebellar hypoplasia 2B (PCH2B)

Subcellular Location

Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.

Protein Families

TRNA-intron endonuclease family

Tissue Specificity

Isoform 1 and isoform 2 are widely expressed at very low level.

Database Links

HGNC: 28422

OMIM: 608753

KEGG: hsa:80746

STRING: 9606.ENSP00000284995

UniGene: Hs.335550

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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