U2AF1L4 Antibody

Datasheet

Code	CSB-PA837850ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA837850ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA837850ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) U2AF1L4 Polyclonal antibody

Uniprot No.

Q8WU68

Target Names

U2AF1L4

Alternative Names

FLJ35525 antibody; MGC33901 antibody; Splicing factor U2AF 26 kDa subunit antibody; U2 auxiliary factor 26 antibody; U2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2 small nuclear RNA auxiliary factor 1 like 4 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1 like protein 4 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2 small nuclear RNA auxiliary factor 1-like protein 4 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1 like 3 antibody; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3 antibody; U2AF1 like protein 3 antibody; U2AF1 RS3 antibody; U2AF1-like protein 3 antibody; U2AF1L3V1 antibody; U2AF1L4 antibody; U2AF1RS3 antibody; U2af26 antibody; U2AF4_HUMAN antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like 3 antibody; U2RNU2 small nuclear RNA auxiliary factor 1 like protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Splicing factor U2AF 26 kDa subunit protein (1-202AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA.

Gene References into Functions

U2AF1L4 gene expression is regulated by cytokines in activated T cells. PMID: 27143377
One of the conservative regions is responsible for the enhancer activity and is able to interact with proteins of HeLa cell nuclear extract. PMID: 22022969
Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26 PMID: 18460468

Subcellular Location

Nucleus. Nucleus speckle. Cytoplasm.

Protein Families

Splicing factor SR family

Tissue Specificity

Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes.

Database Links

HGNC: 23020

OMIM: 601080

KEGG: hsa:199746

UniGene: Hs.351558

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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