UBASH3B Antibody

1. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70. PMID: 24256567
2. The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation. PMID: 28690151
3. The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention. PMID: 26449661
4. targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells PMID: 26766443
5. These results show that TULA-2 is a target of miR-148a-3p PMID: 26516227
6. This recovery involves the phosphorylation of p70 independent of mTOR. PMID: 25271148
7. results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells PMID: 25959715
8. UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity. PMID: 23784775
9. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses. PMID: 20585042
10. hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells. PMID: 15388581

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HGNC: 29884

OMIM: 609201

KEGG: hsa:84959

STRING: 9606.ENSP00000284273

UniGene: Hs.444075