UBE2N Antibody

1. Uev1A-Ubc13 complex catalyzes lysine63-linked ubiquitination of RHBDF2 to promote TACE maturation. PMID: 29069608
2. The malin-laforin complex interacts physically and functionally with the ubiquitin conjugating enzyme E2-N (UBE2N). PMID: 26546463
3. together with UBE2L3 and UBE2D2, synergistically contribute to Parkin-mediated mitophagy PMID: 24906799
4. MiR-205 inhibits DNA damage repair by targeting ZEB1 and Ubc13. PMID: 25476932
5. Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-small ka, CyrillicB mediated matrix metalloproteinase-1 gene regulation. PMID: 25022892
6. Ubc13 was dispensable for transforming growth factor beta (TGFbeta)-induced SMAD activation but was required for activation of non-SMAD signaling via TGFbeta-activating kinase 1 (TAK1) and p38 PMID: 25189770
7. UBE2N inhibition induces neuroblastoma apoptotic cell death via activation of p53 and JNK pathways. PMID: 24556694
8. overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells. PMID: 24610393
9. crystal structure of the Shigella flexneri OspI-Ubc13 complex at 2.3 A resolution; study reveals the molecular basis of Ubc13 deamidation by OspI, as well as a convergence of E2 recognition by bacterial and host proteins PMID: 23633953
10. The structure of the Shigella flexneri OspI and human Ubc13 complex revealed that the interacting surfaces between OspI and Ubc13 are a hydrophobic surface and a complementary charged surface. PMID: 23542009
11. Data show RING finger (RNF) E3 ubiquitin ligase RNF8 dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13/Mms2 with formation of Lys-63 ubiquitin chains, whereas the RNF168 RING domain is a monomer and does not catalyze Lys-6 ubiquitylation. PMID: 22589545
12. the crystal structure of human OTUB1 in complex with human UBC13 and MMS2 PMID: 22679021
13. Data show that growth hormone receptor (GHR) endocytosis requires both ubiquitin-conjugating enzyme Ubc13 and the ubiquitin ligase COOH terminus of Hsp70 interacting protein (CHIP). PMID: 22433856
14. the interation between RAP80 and MDC1 is dependent upon the UBC13 mediated ubiquitination of MDC1 at K-1977 PMID: 21622030
15. entire coding region and splice junctions of RNF8, UBC13 and MMS2 genes were screened for mutations in affected index cases from 123 Northern Finnish breast cancer families PMID: 21774837
16. An NMR-based model of the ubiquitin-bound human complex and the structural basis of lysine 63 chain catalysis. PMID: 12569095
17. Ubc13-Mms2 and Lys63-polyubiquitin chains are associated with signaling cellular stress PMID: 14562038
18. The results in this study allowed identification of important residues of the Ubc13-Mms2 interface, determine a correlation between heterodimer formation and function, and conclude why Mms2 forms a specific complex with Ubc13 but not other Ubc proteins. PMID: 15749714
19. ISGylation of Ubc13 disrupts its ability to form thioester bond with ubiquitin PMID: 16122702
20. These data reveal a critical and unexpected role for vertebrate Ubc13 in the initiation of homologous recombination at the level of double-strand break processing. PMID: 17349954
21. modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism PMID: 17709375
22. Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation. PMID: 17942533
23. the human Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage PMID: 18077395
24. RNF5 associates with JAMP in the ER membrane. This association results in Ubc13-dependent RNF5-mediated noncanonical ubiquitination of JAMP. PMID: 19269966
25. crystal structures of TRAF6 and its complex with the ubiquitin-conjugating enzyme (E2) Ubc13 PMID: 19465916
26. regulation of p53 multimerization that requires the concerted action of JNK and Ubc13 on polysome-bound p53. PMID: 19651615
27. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
28. This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia. PMID: 19034380
29. This paper describes the function of the mouse protein, but suggests the function of the human protein, since both human and mouse proteins are 100% identical. PMID: 12039045

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HGNC: 12492

OMIM: 603679

KEGG: hsa:7334

STRING: 9606.ENSP00000316176

UniGene: Hs.524630