UBN1 Antibody

Code CSB-PA025505GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
UBN1
Alternative Names
UBN1 antibody; Ubinuclein-1 antibody; HIRA-binding protein antibody; Protein VT4 antibody; Ubiquitously expressed nuclear protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human UBN1-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Gene References into Functions
  1. study points to UBN1 as the determinant of H3.3-specific binding and deposition by the HIRA histone chaperone complex. PMID: 26159857
  2. a 184-amino acid region (from amino acids 39 to 223) at the N-terminal region of Ubn-1 was responsible for the interaction with the PDZ2 domain of ZO-1 PMID: 22245583
  3. By a chromatin immunoprecipitation (ChIP) assay, the authors show that Ubn-1 blocks EB1-human herpesvirus 4 DNA interaction. PMID: 21084479
  4. Analyses have revealed that in most cells ubinuclein occurred in the nucleoplasm, but in cells forming tight junctions it is recruited to the plaque structure of the zonula occludens. PMID: 18823282
Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Protein Families
Ubinuclein family
Tissue Specificity
Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Database Links

HGNC: 12506

OMIM: 609771

KEGG: hsa:29855

STRING: 9606.ENSP00000262376

UniGene: Hs.440219

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