ZBED1 Antibody

Code CSB-PA02715A0Rb
Size US$166
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  • Western blot
    All lanes: ZBED1 antibody at 2µg/ml
    Lane 1: EC109 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 79 kDa
    Observed band size: 35 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02715A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA02715A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZBED1 Polyclonal antibody
Uniprot No.
Target Names
ZBED1
Alternative Names
Ac like transposable element antibody; ALTE antibody; BED type zinc finger domain containing protein 1 antibody; DNA replication related element binding factor antibody; dREF homolog antibody; hDREF antibody; KIAA0785 antibody; Putative Ac like transposon antibody; Putative Ac-like transposable element antibody; TRAMP antibody; ZBED1 antibody; ZBED1_HUMAN antibody; Zinc finger BED domain-containing protein 1 antibody; Zinc finger BED type containing 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ZBED1 Antibody (Product code: CSB-PA02715A0Rb) is Non-conjugated. For ZBED1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA02715B0Rb ZBED1 Antibody, HRP conjugated ELISA
FITC CSB-PA02715C0Rb ZBED1 Antibody, FITC conjugated
Biotin CSB-PA02715D0Rb ZBED1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Gene References into Functions
  1. These findings identify DREF as a novel adenovirus E1A C terminus binding partner and provide evidence supporting a role for DREF in viral replication. PMID: 25210186
  2. expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation PMID: 12663651
  3. self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding. PMID: 17209048
  4. hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes PMID: 17220279
Subcellular Location
Nucleus, PML body. Nucleus.; Nucleus, PML body.
Tissue Specificity
Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
Database Links

HGNC: 447

OMIM: 300178

KEGG: hsa:9189

STRING: 9606.ENSP00000370616

UniGene: Hs.131452

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