ZC3H11A Antibody

Code CSB-PA782142
Size US$297
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  • Western blot analysis of extracts from COS cells, using ZC11A antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZC3H11A Polyclonal antibody
Uniprot No.
Target Names
ZC3H11A
Alternative Names
ZC3H11A antibody; KIAA0663 antibody; ZC3HDC11A antibody; Zinc finger CCCH domain-containing protein 11A antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human ZC11A.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that interacts with purine-rich sequences and is involved in nuclear mRNA export; probably mediated by association with the TREX complex.; (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA Export.
Gene References into Functions
  1. Knockout of ZC3H11A in HeLa cells demonstrated that several nuclear-replicating viruses are dependent on ZC3H11A for efficient growth whereas cytoplasmic replicating viruses are not. ZC3H11A binds to short purine-rich ribonucleotide stretches in cellular and adenoviral transcripts. ZC3H11A is important for maintaining nuclear export of mRNAs during stress. Several nuclear-replicating viruses take advantage of this. PMID: 29610341
  2. PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PMID: 22928037
Subcellular Location
Nucleus.
Database Links

HGNC: 29093

OMIM: 613513

KEGG: hsa:9877

STRING: 9606.ENSP00000333253

UniGene: Hs.532399

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