gbb Antibody

Code CSB-PA338804XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) gbb Polyclonal antibody
Uniprot No.
Target Names
gbb
Alternative Names
gbb antibody; 60A antibody; gbb-60A antibody; TGFb-60A antibody; CG5562Protein 60A antibody; Protein glass bottom boat antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) gbb protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for the growth of imaginal tissues and for patterning of the adult wing.
Gene References into Functions
  1. The results indicate that high-fat diet-induced Gbb signaling provokes insulin resistance by increasing tribbles expression. PMID: 27484164
  2. propose that Gbb/Cmpy corelease from presynaptic terminals defines a neuronal protransmission signal PMID: 25453556
  3. Glial Mav modulates muscle expression of Gbb. PMID: 22959350
  4. Studies indicate that glass bottom boat (Gbb) can be processed singly at a prodomain site or a main site to generate two active isoforms, Gbb15 and Gbb38. PMID: 22472647
  5. Data indicate that Gbb38, the large ligand form of the glass bottom boat (Gbb) exhibited greater signaling activity and a longer range than the shorter form Gbb15. PMID: 22472650
  6. Data demonstrate that crimpy (cmpy; CG13253) limits neuronal Gbb activity to permit appropriate regulation of neuromuscular junction growth. PMID: 21750037
  7. The dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development. PMID: 21041451
  8. Gbb/BMP signaling is a new pathway critical for positive regulation of nutrient storage and energy homeostasis during development. PMID: 19914231
  9. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. PMID: 12873382
  10. Gbb globally regulates NMJ function by controlling both the growth and transmitter release properties of the synapse. PMID: 14507784
  11. This present study demonstrates that the central synapses that coordinate motoneuron activation are also reliant on Gbb-dependent retrograde signaling. PMID: 15295025

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Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Expressed in cells of the developing foregut and hindgut during germ band retraction and later embryonic stages. Expressed in the wing disk, mainly in the posterior compartment in the pteropleural and medial regions extending into the progenitors of the s
Database Links

KEGG: dme:Dmel_CG5562

STRING: 7227.FBpp0072036

UniGene: Dm.4758

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