svp Antibody

Code CSB-PA321439XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) svp Polyclonal antibody
Uniprot No.
Target Names
svp
Alternative Names
svp antibody; NR2F3 antibody; CG11502Steroid receptor seven-up antibody; isoform A antibody; Nuclear receptor subfamily 2 group F member 3 antibody; isoform A antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) svp protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Receptor that is required in photoreceptors R1, R3, R4 and R6 during eye development; generation of the ganglion mother cell-2 (GMC-2) fate in the nb7-3 lineage, coinciding with the transition in the expression of HB to KR in the neuroblasts (NBs).
Gene References into Functions
  1. Authors propose that the Seven-up-initiated Imp/Syp gradients create coarse temporal windows within type II neuroblasts to pattern INPs, which subsequently undergo fine-tuned subtemporal patterning. PMID: 28434858
  2. A novel allele of svp was isolated. Expression analysis showed that svp is expressed in two distinct pulses in the embryonic NB5-6T lineage. PMID: 22071101
  3. Appropriate recruitment of the R3/R4 photoreceptor pair mediated by svp is a necessary prerequisite for the correct response of the ommatidial precluster to the Fz polarity signal. PMID: 9651479
  4. expression in combination with prospero and elav identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna PMID: 12606283
  5. svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity. PMID: 15691762
  6. Results suggest that svp is required for the differentiation of Eve-positive pericardial cells and DA1 muscle founders and may have a role in EPC cell growth PMID: 16450585
  7. Enhancer of svp is initially activated by the NK homeodomain factor Tinman (Tin) via two conserved Tin binding sites. PMID: 17098220
  8. Normal patterning of alary muscles along the dorsal vessel was found to be a function of the Bithorax Complex genes abdominal-A (abd-A) and Ultrabithorax (Ubx) but not of the orphan nuclear receptor gene svp. PMID: 19272319

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Subcellular Location
Nucleus.
Protein Families
Nuclear hormone receptor family, NR2 subfamily
Tissue Specificity
Expressed in several embryonic tissues; dorsal vessel, oenocyte and fat body. CNS expression is dynamic and confined to temporally restricted subsections of the NB lineage; expressed in many NB and GMCs, but only a small number of neurons.
Database Links

STRING: 7227.FBpp0082035

UniGene: Dm.20676

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