ada Antibody

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Code	CSB-PA356721XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) ada Polyclonal antibody

Uniprot No.

P06134

Target Names

ada

Alternative Names

ada antibody; b2213 antibody; JW2201Bifunctional transcriptional activator/DNA repair enzyme Ada antibody; Regulatory protein of adaptive response) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase antibody; EC 2.1.1.n11 antibody; Methylphosphotriester-DNA methyltransferase); Methylated-DNA--protein-cysteine methyltransferase antibody; EC 2.1.1.63 antibody; O6-methylguanine-DNA alkyltransferase)] antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) ada protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp-methylphosphotriester. This is a suicide reaction: the enzyme is irreversibly inactivated.; The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene, ada, and other alkylation resistance genes, alkA, alkB and aidB.

Gene References into Functions

NMR assignments of the N-terminal 16 kDa domain of Escherichia coli Ada protein PMID: 15213462
Molecular modeling of the N-terminal 16-kDa domain of Ada protein indicates that the methyl acceptor residue is Cys38. PMID: 16452614
spatial tracking measurements of C-terminal domain of Ada moving on DNA extended by flow; study concludes sliding is mechanism of C-Ada motion along stretched DNA; suggests C-Ada could conduct repair while moving at near the 1-dimensional diffusion limit PMID: 19254550

Protein Families

MGMT family

Database Links

KEGG: ecj:JW2201

STRING: 316385.ECDH10B_2370

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ada Antibody

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