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ada Antibody

Datasheet
Code CSB-PA356721XA01ENV
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Product Details

Full Product Name
Rabbit anti-Escherichia coli (strain K12) ada Polyclonal antibody
Uniprot No.
P06134
Target Names
ada
Alternative Names
ada antibody; b2213 antibody; JW2201Bifunctional transcriptional activator/DNA repair enzyme Ada antibody; Regulatory protein of adaptive response) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase antibody; EC 2.1.1.n11 antibody; Methylphosphotriester-DNA methyltransferase); Methylated-DNA--protein-cysteine methyltransferase antibody; EC 2.1.1.63 antibody; O6-methylguanine-DNA alkyltransferase)] antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli (strain K12)
Immunogen
A synthesized peptide derived from Escherichia coli (strain K12) ada protein
Immunogen Species
Escherichia coli (strain K12)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, Dot blot (guaranteed specific to the immunizing peptide)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
①. 100ug * KLH-conjugated peptide paired with 100ug * BSA-conjugated peptide (positive control);
②. 1ml*pre-immune serum (used as negative control) for free;
③. Rabbit polyclonal antibodies purified by Antigen Affinity;
Quality Guarantee
1. CUSABIO guarantees the antibody purity > 95% confirmed by SDS-PAGE.
2. CUSABIO guarantees the antibody titer > 1: 64,000 confirmed by ELISA.
3. CUSABIO guarantees to offer Peptide-specific Dot blot.
4. CUSABIO guarantees 100% risk-free: No qualified antibody, no charge.
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp-methylphosphotriester. This is a suicide reaction: the enzyme is irreversibly inactivated.; The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene, ada, and other alkylation resistance genes, alkA, alkB and aidB.
Gene References into Functions
  1. NMR assignments of the N-terminal 16 kDa domain of Escherichia coli Ada protein PMID: 15213462
  2. Molecular modeling of the N-terminal 16-kDa domain of Ada protein indicates that the methyl acceptor residue is Cys38. PMID: 16452614
  3. spatial tracking measurements of C-terminal domain of Ada moving on DNA extended by flow; study concludes sliding is mechanism of C-Ada motion along stretched DNA; suggests C-Ada could conduct repair while moving at near the 1-dimensional diffusion limit PMID: 19254550
Protein Families
MGMT family
Database Links
Promotions
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Free antibody trial
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