Ada Antibody

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Code	CSB-PA001268XA01MO
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Ada Polyclonal antibody

Uniprot No.

P03958

Target Names

Ada

Alternative Names

AdaAdenosine deaminase antibody; EC 3.5.4.4 antibody; Adenosine aminohydrolase antibody

Raised in

Rabbit

Species Reactivity

Mus musculus (Mouse)

Immunogen

Recombinant Mus musculus (Mouse) Ada protein

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development.

Gene References into Functions

Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice PMID: 24439080
Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice PMID: 22905401
Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine. PMID: 22184407
ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation. PMID: 21593382
The catalytic mechanism of Mus musculus adenosine deaminase (ADA) has been studied by quantum mechanics and two-layered ONIOM calculations PMID: 20575011
Adenosine deaminase is necessary but not sufficient to confer puromycin aminonucleoside sensitivity to podocytes. PMID: 20649959
adenosine deaminase deficient results in deoxy-ATP accumulation and leads to reduced thymic T cell production PMID: 12163459
Transactivation by a duodenum-specific enhancer requires functional GATA4 binding sites PMID: 12571085
ADA-deficient B cells exhibit a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, and suggest a role for ADA in the survival of cells during antigen-dependent responses. PMID: 14607964
This study provides a basis for investigating the folding kinetics of murine ADA and folding mechanisms of (beta/alpha)8-barrel proteins using 19F NMR sepctroscopy. PMID: 14769019
RUNX1 transcription factor plays a significant role in regulating Ada gene expression in the trophoblast cell lineage. PMID: 16338472
These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation. PMID: 17601796
Progesterone may have an antiseizure effect with the additional finding that decreased levels of adenosine deaminase that would have resulted in increased adenosine levels that exerts anticonvulsant effect via GABA-A receptors. PMID: 19125374
ADA/A2B adenosine receptor double-knockout mice exhibited enhanced pulmonary inflammation and airway destruction PMID: 19494329
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency. PMID: 19633200

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Subcellular Location

Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Lysosome.

Protein Families

Metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family

Tissue Specificity

Detected in brain neurons in the median emninence (at protein level). Expressed in secondary deciduum (at protein level). Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.

Database Links

KEGG: mmu:11486

STRING: 10090.ENSMUSP00000017841

UniGene: Mm.388

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Ada Antibody

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