Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Adar Polyclonal antibody

Uniprot No.

Q9NII1

Target Names

Adar

Alternative Names

Adar antibody; hypnos-2 antibody; CG12598Double-stranded RNA-specific editase Adar antibody; EC 3.5.-.- antibody; Adenosine deaminase that act on RNA antibody; Pre-mRNA adenosine deaminase antibody; RNA-editing deaminase 1 antibody; RNA-editing enzyme 1 antibody; dADAR antibody; dsRNA adenosine deaminase antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Adar protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.

Gene References into Functions

our data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essential for survival of flies in the wild. Moreover, our results suggest a more general role of ADAR in regulating RNA secondary structures in vivo PMID: 28746393
Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons. PMID: 26813350
The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons. PMID: 24137011
loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release PMID: 23127996
results demonstrate a novel role for dADAR protein in rnp-4f 5'-UTR alternative intron splicing regulation which is consistent with a previously proposed model. PMID: 23026215
Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally. PMID: 22658416
the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR PMID: 22210494
Abolishing dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. PMID: 22531175
network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. PMID: 21078670
Our study is the first to systematically characterize the temporal and spatial expression of full-length and truncated dADAR mRNA and protein isoforms during Drosophila embryogenesis. PMID: 19720447
genetic analysis of dADAR substrates in Drosophila PMID: 15522950
importance of ADAR in maintenance of neuronal function and regulatory role in the expression of genes encoding reactive oxygen species scavengers. PMID: 15530657
Two predominant isoforms of dAdar are expressed in gonads and dAdar is transcribed from both the embryonic and the adult promoters. PMID: 19153139

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Tissue Specificity

Expressed in embryonic nervous system; late stage 13 sees ventral nerve cord expression which spreads to brain by stage 16. Expression is maintained through to adulthood.

Database Links

KEGG: dme:Dmel_CG12598

STRING: 7227.FBpp0300329

UniGene: Dm.19

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Adar Antibody

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Target Background