ADAR

ADAR stands for Adenosine Deaminase Acting on RNA. It has no widely - known common aliases. ADAR proteins function by catalyzing the deamination of adenosine to inosine in double - stranded RNA, which can lead to changes in gene expression and RNA editing. They are involved in the regulation of neurotransmitter receptors and ion channels through the RNA editing process.
Mutations in ADAR genes are linked to Aicardi - Goutières syndrome, a severe neurological disease. In terms of drug development, research is in its early stages. Scientists are exploring potential small - molecule modulators to target ADAR activity, aiming to develop therapies for related genetic diseases.