amn Antibody

Code CSB-PA638753XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) amn Polyclonal antibody
Uniprot No.
Target Names
amn
Alternative Names
amn antibody; CG11937Amnesiac neuropeptides [Cleaved into: Amnesiac peptide 24; Amnesiac peptide 30; Amnesiac peptide 56] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) amn protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve.
Gene References into Functions
  1. These results provide compelling evidence that amn is a novel genetic component of the mechanism that regulates thermal nociception in Drosophila. PMID: 19995327
  2. brain functions from knockouts and mutants (REVIEW) PMID: 12270109
  3. Age-related memory impairment in flies results from a specific decrease in amn-dependent middle-term memory. PMID: 14659098
  4. provides support for functional homology between human PACAP-38 and the amn gene product in Drosophilas PMID: 15201281
  5. amn is required in initiation and maintenance of sleep. PMID: 18514063

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Subcellular Location
Secreted.
Tissue Specificity
Enriched expression in the embryonic and larval nervous systems. Strongly expressed in two large neurons that project over all the lobes of the mushroom bodies.
Database Links

KEGG: dme:Dmel_CG11937

STRING: 7227.FBpp0074571

UniGene: Dm.2893

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