csul Antibody

Code CSB-PA866187XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) csul Polyclonal antibody
Uniprot No.
Target Names
csul
Alternative Names
csul antibody; DART5 antibody; CG3730Protein arginine N-methyltransferase 5 antibody; EC 2.1.1.- antibody; JBP1 homolog antibody; Protein arginine N-methyltransferase capsuleen antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) csul protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. Required for arginine symmetrical dimethylation of piwi family proteins, piwi, aub and AGO3, during germline development. Required during oogenesis for pole cell formation in the pathway controlled by oskar (osk) and for abdominal segments during early embryogenesis. Involved in nanos (nos) and germ cell mRNAs localization.
Gene References into Functions
  1. Studies indicate that protein arginine methyltransferase 5 (PRMT5) plays a role in circadian clocks regulated alternative splicing process. PMID: 21941124
  2. results demonstrate a key role for PRMT5 in the regulation of alternative splicing PMID: 20962777
  3. in germline cells, piRNAs are quality-controlled by dPRMT5 that modifies PIWI proteins, in tight association with Tud PMID: 19959991
  4. Dart5 has a role in germ-cell development. PMID: 16753561
  5. Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation. PMID: 17164419

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Subcellular Location
Cytoplasm.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family
Tissue Specificity
Expressed only in ovaries.
Database Links

KEGG: dme:Dmel_CG3730

STRING: 7227.FBpp0088810

UniGene: Dm.3058

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