Anxa1 Antibody

Code CSB-PA001836XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Anxa1 Polyclonal antibody
Uniprot No.
Target Names
Anxa1
Alternative Names
Anxa1 antibody; Anx1Annexin A1 antibody; Annexin I antibody; Annexin-1 antibody; Calpactin II antibody; Calpactin-2 antibody; Chromobindin-9 antibody; Lipocortin I antibody; Phospholipase A2 inhibitory protein antibody; p35 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Anxa1 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation ofthe formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton.
Gene References into Functions
  1. ANXA1 is a novel GnRH target gene in gonadotropes. ANXA1 also may be a target of local GnRH in peripheral tissues and may have a different role than that of ANXA5 PMID: 29213013
  2. ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression. PMID: 27584794
  3. ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process. PMID: 27782092
  4. ANXA1 expression is correlated with TLE activity. Data suggest that ANXA1 plays an important role in TLE by alleviating inflammatory damage and protecting neurons. PMID: 26609771
  5. These findings indicated that down-regulation of ANXA2 by siRNA results in the inhibition of the aberrant dysregulation of paxillin and migration of PASMCs, which suggesting a potential therapeutic effect on HPS-associated PVR. PMID: 26616057
  6. Silencing Anxa1 with shRNA inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 and the expression of differentiation-associated genes during osteogenesis and resulted in reduced differentiation of mesenchymal stem cells. PMID: 26063293
  7. In oxygen-glucose deprivation/reoxygenation, neuronal apoptosis is induced via annexin 1, carried by myosin IIA. PMID: 24939696
  8. annexin A1- formyl peptide receptor 2 pathway mediated the insulin resistance of skeletal muscle, as well as systemic insulin sensitivity. PMID: 25616869
  9. Findings show that intra-axonal synthesis of p35 is required for normal vesicle recycling in developing neurons, and that targeted translational repression provides a novel strategy to investigate extrasomal protein synthesis in neurons PMID: 24254883
  10. ANX A1 down-regulation of PMVEC proliferation in the presence of HPS-rat-serum may be the major cause of aberrant dysregulation of cytoskeletal proteins PMID: 23587191
  11. Results suggest that nitric oxide and ANXA1 act in gastric tumors in disparate pathways. PMID: 23236538
  12. The data showed that annexin A1 exerts an inhibitory effect on COX-2 expression in the macula densa. ANXA1 may be a novel intrinsic modulator of renal juxtaglomerular regulation by inhibition of PGE2 synthesis. PMID: 22791338
  13. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect PMID: 22164217
  14. Endogenous ANXA1 expression at the dorsal root ganglion level is involved in complete Freund's adjuvant-induced inflammatory pain, and intrathecal ANXA1 20 microg microl(-1) produces its anti-nociceptive effect through formyl-peptide-receptor-like 1 PMID: 21990306
  15. Kirenol upregulates nuclear Annexin-1 which interacts with NF-kappaB to inhibit NF-kappaB activity, reduce cytokine expression and thereby attenuate inflammation of arthritic joints. PMID: 21745559
  16. Annexin 1 is able to modulate the reactivity of leukocytes, and more generally, of the experimental inflammatory reaction. PMID: 11729999
  17. annexin i is in rat eosinophils and have a different protein mobilisation from extravasated neutrophils, at least in this acute model of peritonitis. PMID: 12467520
  18. annexin I is externalized from pituitary folliculo-stellate cells by an ABC transporter and the ATP binding cassette transporter A1 is a likely candidate PMID: 12586783
  19. Annexin 1 mediates the disruption of normal cell morphology and inhibits cyclin D1 expression, therefore reducing cell proliferation through proximal modulation of the ERK signal transduction pathway. PMID: 14516791
  20. Study reveals increased expression of the annexin 1 isoform at the mRNA level following moderate contusive spinal cord injury. PMID: 15248295
  21. the actions of ANXA1 in the pituitary gland are independent of Fpr1 but may involve other FPR family members PMID: 17218541
  22. Overexpression of ANNA1 is involved in bladder carcinogenesis induced by bladder calculi and that translocation of the protein may be partly responsible for the effect and as a new marker of differentiation for the histopathological grading of human TCC. PMID: 17994624

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Subcellular Location
Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Lateral cell membrane. Cell membrane; Peripheral membrane protein. Apical cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup.
Protein Families
Annexin family
Tissue Specificity
Detected in eosinophils. Detected in lung, placenta, spleen and thymus (at protein level).
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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