Recombinant Rat Annexin A1 (Anxa1)

1. ANXA1 is a novel GnRH target gene in gonadotropes. ANXA1 also may be a target of local GnRH in peripheral tissues and may have a different role than that of ANXA5 PMID: 29213013
2. ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression. PMID: 27584794
3. ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process. PMID: 27782092
4. ANXA1 expression is correlated with TLE activity. Data suggest that ANXA1 plays an important role in TLE by alleviating inflammatory damage and protecting neurons. PMID: 26609771
5. These findings indicated that down-regulation of ANXA2 by siRNA results in the inhibition of the aberrant dysregulation of paxillin and migration of PASMCs, which suggesting a potential therapeutic effect on HPS-associated PVR. PMID: 26616057
6. Silencing Anxa1 with shRNA inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 and the expression of differentiation-associated genes during osteogenesis and resulted in reduced differentiation of mesenchymal stem cells. PMID: 26063293
7. In oxygen-glucose deprivation/reoxygenation, neuronal apoptosis is induced via annexin 1, carried by myosin IIA. PMID: 24939696
8. annexin A1- formyl peptide receptor 2 pathway mediated the insulin resistance of skeletal muscle, as well as systemic insulin sensitivity. PMID: 25616869
9. Findings show that intra-axonal synthesis of p35 is required for normal vesicle recycling in developing neurons, and that targeted translational repression provides a novel strategy to investigate extrasomal protein synthesis in neurons PMID: 24254883
10. ANX A1 down-regulation of PMVEC proliferation in the presence of HPS-rat-serum may be the major cause of aberrant dysregulation of cytoskeletal proteins PMID: 23587191
11. Results suggest that nitric oxide and ANXA1 act in gastric tumors in disparate pathways. PMID: 23236538
12. The data showed that annexin A1 exerts an inhibitory effect on COX-2 expression in the macula densa. ANXA1 may be a novel intrinsic modulator of renal juxtaglomerular regulation by inhibition of PGE2 synthesis. PMID: 22791338
13. Propofol inhibits the activation of p38 through up-regulating the expression of annexin A1 to exert its anti-inflammation effect PMID: 22164217
14. Endogenous ANXA1 expression at the dorsal root ganglion level is involved in complete Freund's adjuvant-induced inflammatory pain, and intrathecal ANXA1 20 microg microl(-1) produces its anti-nociceptive effect through formyl-peptide-receptor-like 1 PMID: 21990306
15. Kirenol upregulates nuclear Annexin-1 which interacts with NF-kappaB to inhibit NF-kappaB activity, reduce cytokine expression and thereby attenuate inflammation of arthritic joints. PMID: 21745559
16. Annexin 1 is able to modulate the reactivity of leukocytes, and more generally, of the experimental inflammatory reaction. PMID: 11729999
17. annexin i is in rat eosinophils and have a different protein mobilisation from extravasated neutrophils, at least in this acute model of peritonitis. PMID: 12467520
18. annexin I is externalized from pituitary folliculo-stellate cells by an ABC transporter and the ATP binding cassette transporter A1 is a likely candidate PMID: 12586783
19. Annexin 1 mediates the disruption of normal cell morphology and inhibits cyclin D1 expression, therefore reducing cell proliferation through proximal modulation of the ERK signal transduction pathway. PMID: 14516791
20. Study reveals increased expression of the annexin 1 isoform at the mRNA level following moderate contusive spinal cord injury. PMID: 15248295
21. the actions of ANXA1 in the pituitary gland are independent of Fpr1 but may involve other FPR family members PMID: 17218541
22. Overexpression of ANNA1 is involved in bladder carcinogenesis induced by bladder calculi and that translocation of the protein may be partly responsible for the effect and as a new marker of differentiation for the histopathological grading of human TCC. PMID: 17994624

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KEGG: rno:25380

STRING: 10116.ENSRNOP00000023664

UniGene: Rn.1792