AOX1 Antibody

Datasheet

Code	CSB-PA001858XA01RB
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Product Details

Full Product Name

Rabbit anti-Oryctolagus cuniculus (Rabbit) AOX1 Polyclonal antibody

Uniprot No.

P80456

Target Names

AOX1

Alternative Names

AOX1 antibody; AOAldehyde oxidase 1 antibody; EC 1.2.3.1 antibody; Azaheterocycle hydroxylase 1 antibody; EC 1.17.3.- antibody; Retinal oxidase antibody; Retinoic acid synthase antibody

Raised in

Rabbit

Species Reactivity

Oryctolagus cuniculus (Rabbit)

Immunogen

Recombinant Oryctolagus cuniculus (Rabbit) AOX1 protein

Immunogen Species

Oryctolagus cuniculus (Rabbit)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use hypoxanthine and all-trans-retinol as substrate.

Gene References into Functions

Methotrexate is poorly metabolized by human AOX1, in contrast to rabbit. PMID: 26032640
Amino acid substitution experiments reveal structural aspects of substrate specificity of AOX1. PMID: 19910515

Subcellular Location

Cytoplasm.

Protein Families

Xanthine dehydrogenase family

Tissue Specificity

Very high expression in liver and lung. High expression in kidney, pancreas, brain stem and spinal cord. Moderate expression in heart, testis, eye, cerebral cortex and cerebellum. Low expression in stomach and muscle.

Database Links

KEGG: ocu:100008601

STRING: 9986.ENSOCUP00000012025

UniGene: Ocu.2359

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Jak-STAT signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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AOX1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background