APR1 Antibody

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Code	CSB-PA638587XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans apr-1 Polyclonal antibody

Uniprot No.

Q21227

Target Names

apr-1

Alternative Names

apr-1 antibody; K04G2.8Adenomatous polyposis coli protein-related protein 1 antibody; APC-related protein 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans APR1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei. During the L4 larval stage, it is required for the asymmetric division and self-renewal of seam cells. Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1.

Gene References into Functions

Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle PMID: 29348204
These results suggest that beta-catenin and APC may regulate asymmetric divisions or Wnt signaling.[APC] PMID: 17276345
The polarity of APR-1 cortical localization is controlled by PRY-1 (C. elegans Axin), such that PRY-1 controls the polarity of both SYS-1 and WRM-1 asymmetries. PMID: 24762815
Apoptotic cell clearance and migration of the distal tip cell require the APC/APR-1. PMID: 20126385

Subcellular Location

Cell junction, adherens junction. Cytoplasm. Nucleus.

Protein Families

Adenomatous polyposis coli (APC) family

Tissue Specificity

During the L1 stage, expressed in vulval precursor cells (P3-8.p), seam cells and excretory cells.

Database Links

KEGG: cel:CELE_K04G2.8

STRING: 6239.K04G2.8b

UniGene: Cel.16875

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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APR1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background