Recombinant Adenomatous polyposis coli protein-related protein 1 (41365), partial

Code CSB-YP638587CXY
MSDS
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Source Yeast
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Code CSB-EP638587CXY
MSDS
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Source E.coli
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Code CSB-EP638587CXY-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP638587CXY
MSDS
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Source Baculovirus
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Code CSB-MP638587CXY
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
apr-1
Uniprot No.
Alternative Names
apr-1; K04G2.8Adenomatous polyposis coli protein-related protein 1; APC-related protein 1
Species
Caenorhabditis elegans
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei. During the L4 larval stage, it is required for the asymmetric division and self-renewal of seam cells. Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1.
Gene References into Functions
  1. Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle PMID: 29348204
  2. These results suggest that beta-catenin and APC may regulate asymmetric divisions or Wnt signaling.[APC] PMID: 17276345
  3. The polarity of APR-1 cortical localization is controlled by PRY-1 (C. elegans Axin), such that PRY-1 controls the polarity of both SYS-1 and WRM-1 asymmetries. PMID: 24762815
  4. Apoptotic cell clearance and migration of the distal tip cell require the APC/APR-1. PMID: 20126385
Subcellular Location
Cell junction, adherens junction. Cytoplasm. Nucleus.
Protein Families
Adenomatous polyposis coli (APC) family
Tissue Specificity
During the L1 stage, expressed in vulval precursor cells (P3-8.p), seam cells and excretory cells.
Database Links

KEGG: cel:CELE_K04G2.8

STRING: 6239.K04G2.8b

UniGene: Cel.16875

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