Arl13b Antibody

1. High Arl13b expression is associated with medulloblastoma formation. PMID: 29378965
2. Arl13b dysfunction resulted in hennin cell stagnation due to poor growth factor signaling and impaired detection of extracellular electrical gradients. PMID: 26963749
3. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).( PMID: 28487361
4. To investigate whether Arl13b has a role in ciliogenesis in mammalian kidney and whether loss of function of Arl13b leads to cystic kidneys in mammals, we generated a mouse model with kidney-specific conditional knockout of Arl13b Deletion of Arl13b in the distal nephron at the perinatal stage led to a cilia biogenesis defect and rapid kidney cyst formation PMID: 27153923
5. The authors show that the ciliary G-protein Arl13B, mutated in Joubert syndrome, is the guanine nucleotide exchange factor for Arl3, and its function is conserved in evolution PMID: 26551564
6. A new role for Arl13b in actin cytoskeleton remodeling through the interaction with Myh9. PMID: 24777479
7. Early neuroepithelial deletion of ciliary Arl13b reversed the apical-basal polarity of radial progenitors & caused aberrant neuronal placement. Arl13b signaling in primary cilia is crucial for initial formation of a polarized radial glial scaffold. PMID: 23817546
8. guidance cue receptors essential for interneuronal migration localize to interneuronal primary cilia, but their concentration and dynamics are altered in the absence of Arl13b PMID: 23153492
9. By deleting Arl13b in mouse, we induced low-level constitutive GliA function at specific developmental stages and defined a crucial period prior to E10.5 when shifts in the level of GliA cause cells to change their fate PMID: 23014696
10. Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes. PMID: 22554696
11. The role of Arl13b in ciliogenesis and it's interaction with Smo and Shh proteins.Arl13b regulates the ciliary entry of Smo. PMID: 21976698
12. Arl13bhnn mutants have abnormal ventral neural tube patterning due to disrupted sonic hedgehog signaling; in addition, dorsal patterning defects occur from abnormal bone morphogenetic protein signaling. PMID: 21539826

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KEGG: mmu:68146

STRING: 10090.ENSMUSP00000086703

UniGene: Mm.96833