ARL1 Antibody

Code CSB-PA002070XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ARL1 Polyclonal antibody
Uniprot No.
Target Names
ARL1
Alternative Names
ARL1 antibody; ARF3 antibody; YBR164C antibody; YBR1216ADP-ribosylation factor-like protein 1 antibody; Arf-like GTPase 1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ARL1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.
Gene References into Functions
  1. Arl3-Arl1 cascade acts on the cytoplasm-to-vacuole targeting pathway via dynamic nucleotide binding PMID: 28627726
  2. Hac1p restored the Golgi localization of Arl1p inIRE1-deleted cells. Ire1p-Hac1p axis regulated Syt1p phosphorylation, which enhances Arl1p activation, recruitment of Imh1p to the Golgi, and Syt1p interaction with Arl1p. PMID: 26966233
  3. The authors demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L]. PMID: 22594927
  4. gene deletions affecting the Arl1 vesicle-tethering pathways prevent Arl1 activation and membrane localization PMID: 21562219
  5. Findings reveal that activation of Arl1p is regulated in part by Syt1p, and imply that Arl1p activation, by using more than one GEF, exerts distinct biological activities at the Golgi compartment. PMID: 20841378
  6. results are consistent with a model in which ARL1, via regulation of HAL4/HAL5, governs K(+) homeostasis in cells PMID: 15126631
  7. Both ARF-like protein Arl1p and Gcs1p influence the distribution of Imh1p, an Arl1p effector. PMID: 15975906
  8. Arl1p is involved in the anterograde transport from the Golgi to the cell surface of the glycosylphosphatidylinositol (GPI)-anchored plasma-membrane-resident protein Gas1p. PMID: 16926193

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Subcellular Location
Golgi apparatus.
Protein Families
Small GTPase superfamily, Arf family
Database Links

KEGG: sce:YBR164C

STRING: 4932.YBR164C

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