Arp2 Antibody

Code CSB-PA001248XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Arp2 Polyclonal antibody
Uniprot No.
Target Names
Arp2
Alternative Names
Arp2 antibody; Actr14D antibody; Arp14D antibody; CG9901Actin-related protein 2 antibody; Actin-like protein 14D antibody; Actin-like protein 2 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Arp2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.
Gene References into Functions
  1. Cofilin promotes phosphate dissociation and severs filaments, generating new pointed ends and rendering Arp2/3-generated networks competent to bind tropomyosin PMID: 26028436
  2. Arp2/3 has an essential role in the process of secretory cargo expulsion and integration of vesicular membranes with the apical plasma membrane. PMID: 26639106
  3. Abp1 and Arp2/3 complex-mediated actin cytoskeletal dynamics drive both synaptic bouton formation and neuromuscular junction branching. PMID: 24841972
  4. Arp2/3 has a role in PI(4,5)P2 regulation of myoblast fusion in Drosophila PMID: 24821989
  5. The Arp2/3 complex is required for actin cap expansion and pseudocleavage furrow formation during the syncytial blastoderm divisions. PMID: 12007413
  6. two actin regulators, capping protein, a barbed end binding protein, and the Arp2/3 complex, a potent actin assembly nucleator, function to generate properly organized bundles. PMID: 16822838
  7. The data indicate that WASp-dependent Arp2/3 actin polymerization is crucial for apical presentation of Delta, providing a mechanistic link between actin polymerization and Notch signalling. PMID: 19543274

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Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Actin family, ARP2 subfamily
Database Links

KEGG: dme:Dmel_CG9901

STRING: 7227.FBpp0302793

UniGene: Dm.183

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