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| Code | CSB-PA342670XA01SVG |
| Size | US$299 |
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The generation of polyclonal antibodies against ASE1 encompasses repeated immunizations of a rabbit with recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ASE1 protein (43-223aa). After attaining a satisfactory antibody titer, the rabbit serum is collected and then undergoes affinity chromatography purification to obtain ASE1 polyclonal antibodies. Subsequent validation of the ASE1 antibody's functionality occurs through ELISA and WB applications, showcasing its capability to recognize Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ASE1 protein.
The Saccharomyces cerevisiae ASE1 is a key regulator of microtubule dynamics and plays a vital role in the orchestration of cell division. ASE1 is essential for the proper organization and stabilization of the mitotic spindle, particularly in the formation of the spindle midzone, ensuring accurate segregation of chromosomes during mitosis. Additionally, ASE1 contributes to cytokinesis by participating in the organization of the contractile actomyosin ring and facilitating the final steps of cell separation. As a microtubule crosslinking protein, ASE1 bundles and stabilizes microtubules, impacting their interactions and dynamics throughout various cellular processes.
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KEGG: sce:YOR058C
STRING: 4932.YOR058C
