ase1 Antibody

1. Study shows that fission yeast bipolar spindle assembly and chromosome segregation can take place in the absence of both kinesin-5 Cut7 and kinesin-14 Pkl1. In cut7Deltapkl1Delta cells, spindle formation and bipolarity requires the microtubule (MT) antiparallel bundler Ase1 to recruit Cls1 to stabilize MTs. PMID: 28513584
2. Study demonstrated that diffusible microtubule crosslinker Ase1 generated directed microtubule sliding when confined between partially overlapping microtubules. The Ase1-generated forces, directly measured by optical tweezers to be in the piconewton-range, were sufficient to antagonize motor-protein driven microtubule sliding. PMID: 25748652
3. Show that Ase1, a member of the conserved MAP65/PRC1 family of microtubule-bundling proteins, enables the formation of stable antiparallel overlaps through adaptive braking of Kinesin-14-driven microtubule-microtubule sliding. PMID: 21892183
4. An Ase1/Prc1-dependent mechanism that prevents spindle collapse and thus asymmetric division is required for correction of merotelic attachment in anaphase. PMID: 19948483
5. ase1 has a role in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling PMID: 15647375
6. The ase1 protein functions to organize microtubules into overlapping antiparallel bundles both in interphase and mitosis. This dual function suggests that ase1 is differentially regulated through the cell cycle. [ase1] PMID: 15689489
7. loss of Ase1 activates a checkpoint that requires only the Mad3, Bub1, and Mph1, but not Mad1, Mad2, or Bub3 checkpoint proteins PMID: 18562692
8. Cells use a finely tuned cooperative localization mechanism that exploits differences in the geometry and concentration of ase1p binding sites along single and overlapping microtubules. PMID: 18976915
9. Data show that fission yeast kinesin-6 motor klp9p binds to the microtubule antiparallel bundler ase1p at the midzone at anaphase B onset. PMID: 19686686

Show More

Hide All

KEGG: spo:SPAPB1A10.09

STRING: 4896.SPAPB1A10.09.1