atl Antibody

1. Trafficking defects produced by Atlastin dysfunction in motor neurons result in redistribution of presynaptic components and aberrant mobilization of synaptic vesicles. PMID: 28860117
2. this paper shows that atl is required in motor neurons to affect transmitter release PMID: 26906425
3. purified and reconstituted human ATL1 exhibited no in vitro fusion activity. When the cytosolic segment of human ATL1 was connected to the transmembrane (TM) region and C-terminal tail (CT) of Drosophila ATL PMID: 25407413
4. Data indicate that expression of either the K320E or E328R atlastin GTPase (D-ATL) variant led to dominant-negative perturbations of the endoplasmic reticulum. PMID: 25253720
5. Data indicate that GTP hydrolysis is required for atlastin (ATL)-mediated vesicle tethering. PMID: 25825753
6. These data suggest that the C-terminal tail of Atlastin locally destabilizes bilayers to facilitate membrane fusion. PMID: 25555915
7. The homotypic fusion of endoplasmic reticulum membranes is mediated by atlastin through lipid interaction with the C terminus and association of the transmembrane segments. PMID: 22802620
8. increasing the distance of atlastin complex formation from the membrane inhibits fusion, suggesting that this distance is crucial for atlastin to promote fusion PMID: 21930898
9. atlastin dimerizes in the presence of GTPgammaS but is monomeric with GDP or without nucleotide. Oligomerization requires the juxtamembrane middle domain three-helix bundle, as does efficient GTPase activity. PMID: 21690399
10. Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila PMID: 17030474
11. results suggest that Atlastin controls synapse development and ER and Golgi morphogenesis by regulating microtubule stability PMID: 19341724
12. results demonstrate that Atlastin mediates membrane tethering and fusion and strongly suggest that it is the GTPase activity that is required for endoplasmic reticulum homotypic fusion PMID: 19633650

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KEGG: dme:Dmel_CG6668

STRING: 7227.FBpp0084036

UniGene: Dm.31277