Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) mei-41 Polyclonal antibody

Uniprot No.

Q9VXG8

Target Names

mei-41

Alternative Names

mei-41 antibody; CG4252Serine/threonine-protein kinase ATR antibody; EC 2.7.11.1 antibody; Ataxia telangiectasia and Rad3-related protein homolog antibody; ATR homolog antibody; dATR antibody; Meiotic protein 41 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) mei-41 protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination. Phosphorylates grp/CHK1. Phosphorylates 'Ser-137' of histone variant H2AX/H2AV at sites of DNA damage, thereby regulating DNA damage response mechanism. Essential for the DNA damage checkpoint in larval imaginal disks and neuroblasts and for the DNA replication checkpoint in the embryo. Has also an essential role during early nuclear divisions in embryos, where it is required to delay mitosis in response to incomplete DNA replication. Also plays an important role during meiosis, where it may monitor double-strand-break repair during meiotic crossing over, to regulate the progression of prophase I, and to enforce metaphase I delay observed at the end of oogenesis.

Gene References into Functions

Overexpression of the Drosophila ATR homologue mei-41 elicits an effectual DNA damage response irrespective of irradiation. PMID: 30202398
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM. PMID: 26000719
Drosophila ATR has distinct activities in the regulation of meiotic DNA damage and repair PMID: 22024169
MEI-41 acts not in a single rigid signal transduction pathway, but in multiple molecular contexts to carry out its many functions PMID: 12807779
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins. PMID: 16203987
A significant component of the defects in the later steps of DNA homologous recombination repair are due to loss of MEI-41-dependent cell cycle regulation. PMID: 17194776
Mutations in the ATR/Chk2 DNA damage signal transduction pathway dramatically suppress these axis specification defects, but do not restore retrotransposon or Stellate silencing. PMID: 17199040

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Subcellular Location

Nucleus.

Protein Families

PI3/PI4-kinase family, ATM subfamily

Database Links

KEGG: dme:Dmel_CG4252

STRING: 7227.FBpp0074047

UniGene: Dm.23161

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mei-41 Antibody

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