AURKB Antibody

Datasheet
Code CSB-PA002458XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6NW76
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) AURKB protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Aurora kinase B (EC 2.7.11.1) (Serine/threonine kinase A) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase aurora-B) aurkb stka
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names aurkb
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Phosphorylates 'Ser-10' of histone H3 during mitosis (By similarity). Plays an essential role in early embryonic development.
Subcellular Location Nucleus, Chromosome
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
Database Links

STRING: 7955.ENSDARP00000054822

UniGene: Dr.32625

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