AURKB, a key player in the aurora kinase family, is encoded by our genes and plays a crucial role in the cell division process. It's responsible for phosphorylating various proteins, which helps regulate the alignment of chromosomes, the assembly of the spindle, and ensures the cell cycle progresses correctly. This mechanism is vital for the precise and orderly division of cells. On the biological front, irregularities in AURKB's expression are closely tied to the development of various cancers, making it a key area of interest in cancer research. As such, AURKB is being explored as a potential therapeutic target for developing new strategies against cancer. Understanding how AURKB is regulated and how its impact on cell division contributes to cancer development is crucial for advancing cancer treatments.
AURKB Antibody (CSB-PA002458EA01HU)
Validated Data
Immunofluorescence staining of Hela cells with CSB-PA002458EA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002458EA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA002458EA01HU at dilution of 1:100
The following AURKB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
AURKB Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002458EA01HU | AURKB Antibody | Human | ELISA, IHC, IF |
CSB-PA000926 | AURKB Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
CSB-PA000927 | AURKB Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA070260 | Phospho-AURKB (Y12) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA070261 | Phospho-AURKB (T232) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
CSB-RA230110A0HU | AURKB Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
AURKB Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002458HU CSB-EP002458HU CSB-BP002458HU CSB-MP002458HU CSB-EP002458HU-B |
Recombinant Human Aurora kinase B (AURKB) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |