Agtr2 Antibody

Code CSB-PA001466ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Agtr2 Polyclonal antibody
Uniprot No.
Target Names
Agtr2
Alternative Names
Agtr2 antibody; Type-2 angiotensin II receptor antibody; Angiotensin II type-2 receptor antibody; AT2 antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus
Immunogen
Recombinant Rattus norvegicus Agtr2 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Gene References into Functions
  1. The present study demonstrated that renal transplantation may cause angiotensin II receptor-mediated vascular contractility associated with changes of epigenetic mechanisms. PMID: 29393347
  2. Following restraint stress, AT2 receptors in the pre-limbic cortex modulate the tachycardiac component of the autonomic response. PMID: 28695320
  3. Activation of angiotensin II type 2 Receptor enhances muscle microvascular, oxygenation, and Insulin sensitivity. PMID: 29186390
  4. Study demonstrates that a tonic activation of angiotensin II type II receptors could contribute to the general reduction in muscle contractility in the course of experimental gastrointestinal inflammation. PMID: 28160390
  5. The research data show that the angiotensin (Ang) converting enzyme 2/Ang-(1-7) regulates lipid metabolism in the adipose tissue and liver. PMID: 28438644
  6. The androgen receptor-mediated ERK1/2 MAP kinase-signaling pathway may be a key mechanism by which testosterone downregulates AT2R expression. PMID: 27765882
  7. This study demonstrates that AT2R expression levels in DRG neurons remain constant from early foetal life until adulthood. PMID: 27825832
  8. Increased AT2R expression within the nucleus of the solitary tract/dorsal motor nucleus of the vagus of spontaneously hypertensive rats was effective at improving baroreflex function but not mean arterial pressure. PMID: 27469059
  9. in combination with dopamine D3 receptors enhances natriuresis and diuresis via ERK1/2-MAPK pathway PMID: 25770092
  10. Stress and stress plus ethanol may alter endothelial signaling via AT2-receptors, and thereby increase blood pressure. PMID: 25238020
  11. In young rats, the AT2R modulates the response to AngII, blunting renal vasoconstriction. This effect is attenuated with age in association with a developmental reduction in renal AT2R expression. PMID: 25119338
  12. AT2 receptors can inhibit the secretion of norepinephrine from the locus coeruleus to the hypothalamus. The attenuation of presynaptic action of AT2 receptor may play a role in the pathophysiological mechanism of stress-induced hypertension in rats. PMID: 25562714
  13. the angiotensin receptor blocker valsartan induced cardioprotection associated with upregulating AT2 receptor protein and mRNA expression after ischaemia-reperfusion in isolated rats. PMID: 26137805
  14. Our findings suggested that AT2R overexpression triggers the apoptosis of INS-1 cells and dysfunction in insulin secretion PMID: 25430897
  15. Data suggest that central AT2 receptor may represent a potential new therapeutic target for the treatment of neurogenic hypertension. PMID: 25655919
  16. Data showw that blocking of AT2 receptors and inhibition of either endothelial nitric oxide synthase (eNOS) or extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) restored Ang II-induced contraction in obese rats. PMID: 25170617
  17. Angiotensin type 2 receptor in the intermediolateral cell column tonically inhibits sympathetic nerve activity. PMID: 23871345
  18. Angiotensin II acts at the AT2R to stimulate ROMK channel activity in cortical collecting ducts from high potassium-fed rats. PMID: 25100281
  19. Data suggest that angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension. PMID: 24958505
  20. Angiotensin II type 2 receptor stimulation improves fatty acid ovarian uptake is associated with polycystic ovary syndrome and hyperandrogenemia. PMID: 24971613
  21. Study revealed increased promoter methylation and resultant AT2R gene repression in the developing brain linking perinatal stress and a pathophysiological consequence of heightened vulnerability of brain hypoxic-ischemic encephalopathy in the neonate PMID: 23978469
  22. Long term AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and decreases blood pressure in obese Zucker rats. PMID: 23823602
  23. AT2R plays a significant role in T3-induced cardioprotection. PMID: 23807455
  24. Angiotensin II type 2 receptor antagonists could be particularly useful in the treatment of chronic pain and hypersensitivity associated with abnormal nerve sprouting PMID: 23255326
  25. The AT2R functions as an insulinotropic mediator. AT2R and its downstream signaling pathways may be potential therapeutic targets for diabetes. PMID: 24085035
  26. The small molecule ATR antagonist, EMA401, is in clinical development as a novel analgesic for the relief of neuropathic pain. PMID: 23489258
  27. The expression of both angiotensin AGTRa and AGTR2 receptors was increased in the myocardium of overfed rats, and ischemia-reperfusion increased the expression of both receptors in control rats but reduced it in overfed rats. PMID: 23383303
  28. Angiotensin II receptor antagonism reduced distal nephron acidification. PMID: 22832514
  29. AT2R is involved in early adipocyte differentiation, while in mature adipocytes and in a model of insulin resistance AT2R activation restores normal adipocyte morphology and improves insulin sensitivity. PMID: 23149621
  30. The effects of stress on adrenomedullary AT(1A) and AT(2) receptor expression may contribute to allostatic changes, such as regulation of catecholamine biosynthesis. PMID: 22911895
  31. Up-regulation of AT2 might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition PMID: 21752621
  32. This data provides a case for AT2 receptors playing a protective role in rat mesangial cells independent of the effects of blood pressure control. PMID: 22287496
  33. An interaction of the angiotensin II receptor subtype 2 (AT2-R) with vascular endothelial growth factor receptor 2 (VEGFR2) in the neonatal brain microvasculature that produces protective effects which are associated with injury tolerance. PMID: 22569153
  34. Investigation of a potential role of AT receptors demonstrates the presence of an active signal transduction mechanism in postnatal day-15 rat hindbrain, representing a function critical for cerebellar development and neuronal differentiation. PMID: 22120166
  35. results indicate that the renal AT(2) receptor, via nitric oxide/cGMP/Sp1 pathway, regulates AT(1 )receptor expression and function, which may be important in the regulation of sodium excretion and blood pressure PMID: 22504846
  36. Study describes a novel transgenic rat model that overexpresses the AT2R in important cardiovascular tissues. AT2R overexpression in the adrenal zona glomerulosa counteracts the ang II induced cell proliferation and has no effect on aldosterone production PMID: 22318954
  37. Testosterone improves cardiac function and alters angiotensin II type 2 receptors in isoproterenol-induced heart failure. PMID: 22424324
  38. The AT2R constitutively induced apoptosis in rat neonatal cardiac myocytes in dose-dependent patterns. PMID: 21967903
  39. Angiotensin II receptor activation in youth triggers the upregulation of inflammatory cytokines and the production of reactive oxygen species, thereby inducing later insulin resistance and hypertension. PMID: 22129514
  40. The resulting NO production antagonizes AT(1)R-mediated ROS and dampens L-type Ca(2+) currents. The ensuing signaling changes in the NTS may counteract the deleterious effects of AT(1)R on cardiovascular function. PMID: 22378773
  41. Candesartan improved AT(2)R neuronal function and Akt phosphorylation, which were associated with sensory nerve defects and insulin sensitivity in the fructose-treated rats. PMID: 22357959
  42. Data indicate that both AT1R and AT2R regulate action of insulin on skeletal muscle microvascular and skeletal muscle metabolism. AT2R activity is required for normal microvascular and metabolic responses to insulin. PMID: 21896931
  43. modulate inflammation through STAT3 phosphorylation and TNFalpha production PMID: 21288138
  44. results suggest that the local renin-angiotensin system is activated in diabetic skin and Angiotensin II receptors type 1 and 2 are likely to mediate the pathological changes of diabetic skin PMID: 21484513
  45. Oxygen availability in clipped kidney is maintained by angiotensin II generation, angiotensin II type 2 receptors, and nitric oxide synthase. Angiotensin can prevent hypoxia in kidney challenged with reduced perfusion pressure. PMID: 18158356
  46. The present study provides direct evidence that AT2R plays a beneficial role in balloon injury-induced neointimal hyperplasia. PMID: 21468559
  47. Ang III and AT2R signaling may have a role in the pathophysiology of aldosterone breakthrough. PMID: 21303953
  48. Data show that AT(2) antibodies recognized postmitotic Purkinje cells, labeling the somata of these cells at all the stages studied, from P8 to P60, suggesting that PCs express these receptors from early stages of development until adulthood. PMID: 21146214
  49. Studies indicate a gender-specific role for the ATR in renal autoregulation was evident in females, which may be a direct vascular ATR effect. PMID: 21189402
  50. Data show that direct ATR stimulation reduces early renal inflammatory responses and improves production of NO and cGMP in renovascular hypertension independent of blood pressure reduction. PMID: 21189405

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.
Database Links
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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