Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans bar-1 Polyclonal antibody

Uniprot No.

Q18825

Target Names

bar-1

Alternative Names

bar-1 antibody; pvl-1 antibody; spy-1 antibody; C54D1.6Beta-catenin/armadillo-related protein 1 antibody; Protruding vulva protein 1 antibody; Suppressor of polyray 1 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans bar-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectodermal cell P12 specification, movement, body length, male tail development and dauer induction. Functionally redundant to wrm-1 and hmp-2.

Gene References into Functions

Neuroprotection from mutant huntingtin toxicity requires FOXO partner bar-1/Beta-catenin. PMID: 22956852
promoter elements necessary for bar-1 expression in several cell types, including a 321-bp element sufficient for expression in ventral cord neurons and a 1.1-kb element sufficient for expression in the developing vulva and adult seam cells PMID: 15282167
Caenorhabditis elegans, both WRM-1/beta-catenin and LIT-1 kinase localize to the anterior cell cortex during asymmetric cell division but to the nucleus of the posterior daughter afterward PMID: 16077003
These results suggest that beta-catenin and APC may regulate asymmetric divisions or Wnt signaling. PMID: 17276345
Membrane trafficking regulated by ipla-1 provides a mechanism to control the cortical asymmetry of beta-catenin. PMID: 18497747
NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell. PMID: 19654209

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Subcellular Location

Cytoplasm. Nucleus. Membrane. Cell junction.

Protein Families

Beta-catenin family

Tissue Specificity

Expressed in body wall muscle cells, hypodermal seam cells, gonad sheath cells and vulval precursor cells.

Database Links

KEGG: cel:CELE_C54D1.6

STRING: 6239.C54D1.6

UniGene: Cel.5480

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bar-1 Antibody

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