GNBP1 Antibody

Code CSB-PA873594XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) GNBP1 Polyclonal antibody
Uniprot No.
Target Names
GNBP1
Alternative Names
GNBP1 antibody; CG6895Gram-negative bacteria-binding protein 1 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) GNBP1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a key role in innate immunity by acting as a pattern recognition receptor for beta-1,3-glucan from fungi and lipopolysaccharide from Gram-negative bacteria. Upon recognition of invading microorganism-derived products, acts upstream of protease spz processing enzyme SPE to activate the Toll pathway and to induce the expression of antimicrobial peptides drosomycin, cecropin and attacin.
Gene References into Functions
  1. GNBP1 acts upstream of the Toll ligand Spatzle and works in the defense against Gram-positive bacterial infection in Drosophila PMID: 14722090
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Note=Secreted and attached to the membrane by a GPI-anchor.
Protein Families
Insect beta-1,3-glucan binding protein family
Database Links

KEGG: dme:Dmel_CG6895

STRING: 7227.FBpp0074817

UniGene: Dm.2810

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