GNBP3 Antibody

Code CSB-PA885665XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) GNBP3 Polyclonal antibody
Uniprot No.
Target Names
GNBP3
Alternative Names
GNBP3 antibody; CG5008Gram-negative bacteria-binding protein 3 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) GNBP3 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade.
Gene References into Functions
  1. Data show that Spn1 is an active protease inhibitor of the serpin superfamily, and support a role of Spn1 as a repressor of GNBP3-dependent Toll activation upon fungal infection. PMID: 21576362
  2. GNBP3 agglutinates fungal cells & activates melanization in a Toll-independent manner. GNBP3 assembles "attack complexes", which comprise phenoloxidase and the necrotic serpin. PMID: 20201042
  3. Here, we report that GNBP3 is a pattern recognition receptor that is required for the detection of fungal cell wall components. Strikingly, we find that there is a second, parallel pathway acting jointly with GNBP3. PMID: 17190605
  4. N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) has a role in beta-glucan recognition PMID: 19692333
  5. GNBP3-N terminal crystals belonged to the monoclinic space group C2, with unit-cell parameters a = 134.79, b = 30.55, c = 51.73 A, beta = 107.4 degrees, and diffracted to 1.7 A using synchrotron radiation. PMID: 19724120

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Subcellular Location
Secreted.
Protein Families
Insect beta-1,3-glucan binding protein family
Database Links

KEGG: dme:Dmel_CG5008

STRING: 7227.FBpp0076237

UniGene: Dm.898

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