BicD Antibody

Code CSB-PA321454XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) BicD Polyclonal antibody
Uniprot No.
Target Names
BicD
Alternative Names
BicD antibody; CG6605Protein bicaudal D antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) BicD protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components.
Gene References into Functions
  1. 2.2 A resolution crystal structure of a cargo-binding region of the dynein adaptor Bicaudal-D (BicD), which reveals a parallel coiled-coil homodimer PMID: 23723415
  2. Results implicate BicD as a new player in clathrin-associated trafficking processes and show a novel requirement for microtubule-based motor transport in the synaptic vesicle cycle. PMID: 20111007
  3. component of a selective dynein motor complex that drives transcript localization in a variety of tissues PMID: 11740552
  4. Various processes in which BicD is involved during embryogenesis (review) PMID: 16320833
  5. while BicD might contribute to recruitment of dynein to the cargo it is not absolutely required for such dynein localization PMID: 19018277

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Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
BicD family
Tissue Specificity
In ovaries, expressed in oocyte and nurse cells.
Database Links

KEGG: dme:Dmel_CG6605

STRING: 7227.FBpp0303259

UniGene: Dm.3232

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