bowl Antibody

Code CSB-PA895179XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) bowl Polyclonal antibody
Uniprot No.
Target Names
bowl
Alternative Names
bowl antibody; CG10021 antibody; Protein bowel antibody; Brother of odd with entrails limited antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) bowl protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Putative transcription factor. Required for leg joint formation, acting downstream of Notch to pattern the leg tarsal segments. Functions in the terminal pathway during embryogenesis, acting downstream of tll in the posterior of the embryo. Acts in a hierarchy downstream of drm and lin during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.
Gene References into Functions
  1. we find that C15 interacts physically with the Dll activator through contacts between their homeodomain and binds competitively with Dll to adjacent cognate sites on LAE, adding potential new layers of regulation by C15. Lastly, we show that C15 and Bowl activities regulate also rn expression PMID: 28394894
  2. Lines acts antagonistically to bowl in hub specification, establishing bowl as a positively acting factor in the development of the testis niche. PMID: 21486923
  3. Bowl is part of a genetic program that suppresses the formation of supernumerary appendages specifically in the fly's head. PMID: 18662773
  4. Reciprocal roles are reported for bowl and lin in specifying the peripodial epithelium and the disc proper of the wing. PMID: 18701548
Subcellular Location
Nucleus.
Tissue Specificity
Expressed at the termini of the blastoderm embryo in three domains; strongly expressed at the posterior pole, relatively weakly expressed at the anterior pole and expressed in a broad transverse stripe just anterior to the presumptive cephalic furrow. Sub
Database Links

KEGG: dme:Dmel_CG10021

STRING: 7227.FBpp0297869

UniGene: Dm.4025

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