bun Antibody

Datasheet

Code	CSB-PA634511XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) bun Polyclonal antibody

Uniprot No.

Q24522

Target Names

bun

Alternative Names

bun antibody; shs antibody; CG42281Protein bunched antibody; class 1/class 3/D/E isoforms antibody; Protein shortsighted antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) bun protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis. May be required for the transmission of the dpp signal and for a morphogenetic movement of the medulla in the brain that reorients the second optic lobe relative to the first. Plays a role in determining proper dorsal cell fates leading to the formation of the dorsal appendages.

Gene References into Functions

The data suggest the model that Bunched and Madm functionally interact with the TOR pathway in the cytoplasm to regulate the growth and subsequent division of intestinal stem cells. PMID: 26323255
Bunched, a negative regulator of Notch, is involved in sleep homeostasis through a neuron-glia signal pathway. PMID: 21549599
bun regulates the level of Notch stimulation to position the boundary between centripetally migrating and stationary columnar follicle cells PMID: 16223477
In anterior follicle cells exposed to a Dpp morphogen gradient, high and low levels of slbo and bun, respectively, are established by modulation of Notch signaling to direct threshold cell fates. PMID: 17383627
BunDN has dominant negative activity useful to identify bun functions and genetic interactions that occur during tissue patterning. PMID: 17600691
we hypothesize that the long TSC-22 protein is a functional homolog of BunA in growth regulation, and that it is antagonized by the short TSC-22 protein PMID: 18226226
Drosophila TSC-22/DIP/Bun proteins are necessary for cellular growth, proliferation, and survival both in culture and in an epithelial context. PMID: 18375761
bun acts as a specific factor in regulating neuroblast mitotic activity during the development of alpha/beta neurons. PMID: 19328837

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

TSC-22/Dip/Bun family

Tissue Specificity

Anterior dorsal follicle cells at stages 10-12 of oogenesis.

Database Links

UniGene: Dm.7349

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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bun Antibody

Product Details

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Customer Reviews and Q&A

Target Background