CAB39 Antibody

Code CSB-PA004381XA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CAB39 Polyclonal antibody
Uniprot No. Q9Y376
Target Names CAB39
Alternative Names Cab39 antibody; CAB39_HUMAN antibody; Calcium binding protein 39 antibody; Calcium-binding protein 39 antibody; CGI 66 antibody; CGI-66 antibody; CGI66 antibody; MO25 alpha antibody; MO25 antibody; Mouse protein 25 alpha antibody; Protein Mo25 antibody
Raised in Rabbit
Species Reactivity Homo sapiens (Human)
Immunogen Recombinant Homo sapiens (Human) CAB39 protein
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Gene References into Functions
  1. miR-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion PMID: 28197410
  2. These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases. PMID: 23296203
  3. Authors conclude that miR-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K/AKT pathway indirectly. PMID: 22179124
  4. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. PMID: 21423148
  5. study describes structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 function PMID: 19892943
  6. STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 PMID: 18854318
  7. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet separate from other polarity events. PMID: 19386264
  8. ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 activation. PMID: 19513107
  9. plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK signaling pathway PMID: 28605041

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Subcellular Location Cytoplasm.
Protein Families Mo25 family
Database Links

HGNC: 20292

OMIM: 612174

KEGG: hsa:51719

STRING: 9606.ENSP00000258418

UniGene: Hs.603930

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