cac Antibody

1. Motor defects in TDP-43 mutants can be rescued by expression of cacophony in motor neurons and by expression in two pairs of neurons in the brain. PMID: 28847811
2. the novel R1673P allele of CACNA1A produces neurodegenerative phenotypes in flies and human, likely due to a toxic gain of function PMID: 28742085
3. cacophony (cacTS2), a mutation of the Drosophila presynaptic Ca++ channel alpha1 subunit gene, is a particularly potent seizure-suppressor mutation, reverting seizure-like phenotypes for parabss1 and other BS mutants PMID: 26771829
4. Cac regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PMID: 25811491
5. Homeostatic depression is achieved by decreased presynaptic Cav2.1 calcium channel abundance and calcium influx. PMID: 25884248
6. Dopaminergic neurons with mutant Ca2+ channel cacophony are inherently resistant to MPP+-induced neurodegeneration. PMID: 25445363
7. cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications PMID: 23959639
8. Vesicle exocytosis depends on cacophony, TRP and TRPL. PMID: 22952921
9. Homeostatic increase in Ca(2+) influx and release is blocked by a point mutation in the presynaptic CaV2.1 channel. PMID: 22633807
10. role of mutation in courtship and other behaviors PMID: 12242229
11. Dmca1A is an allele of the N-type calcium channel locus that caused synaptic undergrowth PMID: 12896973
12. Localization of cacophony on presynaptic terminals at neuromuscular synapses. PMID: 14715960
13. Data show that the Drosophila cacophony ts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation PMID: 16820014
14. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system. PMID: 17114050
15. Cacophony protein plays a key role in developmental regulation of Drosophila neuronal excitability. PMID: 17267561
16. Neuronal overexpression of cac partially rescues the viability and physiological defects in stj mutants, indicating a role for the alpha(2)delta Ca(2+) channel subunit in mediating the proper localization of an alpha(1) subunit at synapses. PMID: 18391075
17. cac encoded Ca(v)2-type calcium channels regulate action potential (AP)-independent release of neurotransmitter at excitatory cholinergic synapses PMID: 19004991

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KEGG: dme:Dmel_CG43368

STRING: 7227.FBpp0298326

UniGene: Dm.2395