cad Antibody

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Code	CSB-PA362588XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) cad Polyclonal antibody

Uniprot No.

P09085

Target Names

cad

Alternative Names

cad antibody; CG1759Homeotic protein caudal antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) cad protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora.

Gene References into Functions

In this study, ChIP/chip datasets are analyzed using the corresponding PWMs for the well-studied TFs; CAUDAL, HUNCHBACK, KNIRPS and KRUPPEL, to determine the distribution of predicted binding sites. All four TFs are critical regulators of gene expression along the anterio-posterior axis in early Drosophila development PMID: 27264535
Using a systematic series of deletion mutants (all containing the intact DNA-binding homeodomain) we discovered that the C-terminal region of Caudal contributes to the preferential activation of the fushi tarazu (ftz) Caudal target gene. PMID: 26018075
Bicoid acts through a 63 nt response element in the caudal 3' untranslated region that includes a single miR-2 target site. Four predicted Bicoid splice isoforms are capable of caudal repression; all require the microRNA target for repression. PMID: 23910663
Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region. PMID: 23903193
Bicoid recruits Bin3 to the caudal 3' UTR. PMID: 21262214
Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation. PMID: 12368268
The caudal homeodomain protein activates Drosophila E2F gene expression. PMID: 12466526
In this study, we have identified the binding sites for bHLH-PAS proteins, referred to as CNS midline element (CME), in the 5'-flanking region of the Drosophila caudal gene. PMID: 17207870
study shows that the intestinal homeobox gene Caudal regulates the commensal-gut mutualism by repressing nuclear factor kappa B-dependent antimicrobial peptide genes PMID: 18218863
Age- and oxidative-stress-related upregulation of the caudal gene is mediated by the NF-kappaB binding site located in the 5'-flanking region of the caudal gene. PMID: 18656526

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Subcellular Location

Nucleus.

Protein Families

Caudal homeobox family

Tissue Specificity

Maternally localized in an anteroposterior gradient in the syncytial blastoderm. Also expressed in the pole cells. Zygotically localized in the primordia of the terminal abdominal segment, the hindgut and in the posterior midgut rudiment. Expressed in the

Database Links

KEGG: dme:Dmel_CG1759

STRING: 7227.FBpp0080942

UniGene: Dm.2073

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cad Antibody

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Target Background