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crt-1 Antibody

Datasheet
Code CSB-PA004458XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans crt-1 Polyclonal antibody
Uniprot No.
P27798
Target Names
crt-1
Alternative Names
crt-1 antibody; Y38A10A.5Calreticulin antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans crt-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Related Products

crt-1 Proteins

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Target Background

Function
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegeneration.
Gene References into Functions
  1. Data show that the neuroligin-like GLIT-1, the canonical apoptosis pathway and the calreticulin CRT-1 are required to prevent 6-OHDA-induced dopaminergic neurodegeneration. PMID: 29346364
  2. CRT-1 controls by as little as 2-fold the abundance of UNC-52/perlecan, an essential hemidesmosome extracellular matrix ligand. PMID: 20153198
  3. Tunicamycin-induced UPR pathway culminates in the up-regulation of crt-1, which protects the worm from deleterious accumulation of unfolded proteins in the ER PMID: 17651753
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Calreticulin family
Database Links
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  Email: [email protected]
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Service

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Protein Service

Gene Synthesis Service

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