cas Antibody

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Code	CSB-PA748742XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) cas Polyclonal antibody

Uniprot No.

Q7M3M8

Target Names

cas

Alternative Names

cas antibody; ming antibody; CG2102Transcription factor castor antibody; Protein ming antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) cas protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Transcription factor that specifies expression of key genes in developing central nervous system (CNS). Essential for many, if not all, late developing neuroblastoma (NB) sublineages. Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively. Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells. Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes. Controls engrailed (en) expression in the ventral nerve chord.

Gene References into Functions

The expression of castor protein is regulated by ABD-D protein in promoter region of castor gene. PMID: 24219869
Castor (Cas) is a nuclear protein that is expressed in follicle stem cells and early follicle cell precursors and then is restricted to differentiated polar and stalk cells once egg chambers form PMID: 23610413
a novel function for castor in regulating neuropeptide gene expression. PMID: 23010511
These results indicate that cas could be directly suppressed by Repo. PMID: 19635453

Subcellular Location

Nucleus.

Tissue Specificity

Expressed in a specific subset of neuroblasts in the ventral nerve chord and the procephalic region in the embryo. Expressed in many, if not all, late delaminating NBs, and in early NBs, but only after they have undergone several rounds of ganglion mother

Database Links

KEGG: dme:Dmel_CG2102

STRING: 7227.FBpp0078374

UniGene: Dm.1871

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cas Antibody

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