Dcp-1 Antibody

1. drICE and dcp-1 function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE but not dcp-1, but required drICE and dcp-1 when drICE activity was reduced via hypomorphic mutation. PMID: 26022392
2. Autophagy suppresses Dcp-1-mediated apoptotic cell death, whereas Dcp-1 positively regulates autophagy, possibly through feedback regulation. PMID: 20100334
3. novel characteristic morphological features of egg chambers lacking both dcp-1 and pita functions in the germline cells; suggested an essential role of dcp-1 and/or pita during mid-oogenesis PMID: 15547953
4. A double-mutant analysis between drICE and death caspase-1 (dcp-1), another effector caspase, reveals that some cells (type I) strictly require drICE for apoptosis, whereas other cells (type II) require either drICE or dcp-1. PMID: 16645642
5. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death in Drosophila. PMID: 18794330
6. HeT-A mRNA is derepressed in mRNA degradation mutants dcp1, indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates. PMID: 19651888

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KEGG: dme:Dmel_CG5370

STRING: 7227.FBpp0071971

UniGene: Dm.4849