cav Antibody

Code CSB-PA853321XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) cav Polyclonal antibody
Uniprot No.
Target Names
cav
Alternative Names
cav antibody; anon antibody; fe antibody; 1G5 antibody; anon1G5 antibody; Hoap antibody; IG5 antibody; CG6219 antibody; Telomere-binding protein cav antibody; Anonymous fast evolving 1G5 antibody; HP1/ORC-associated protein antibody; HOAP p55 antibody; Protein caravaggio antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) cav protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Binds to chromosome ends in a sequence-dependent manner and is required for telomere capping.
Gene References into Functions
  1. genetic and biochemical assays indicate a repressing activity for HOAP PMID: 21695246
  2. HOAP has a role in functional centric heterochromatin PMID: 12826664
  3. HOAP-depleted telomeres activate both the DNA-damage response and the spindle assembly checkpoint. PMID: 18246067
  4. Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection PMID: 19181850
  5. HOAP interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila PMID: 19190990

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Subcellular Location
Nucleus. Chromosome, telomere.
Database Links

KEGG: dme:Dmel_CG6219

STRING: 7227.FBpp0083943

UniGene: Dm.20244

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