Recombinant Drosophila melanogaster Telomere-binding protein cav (cav)

Code CSB-YP853321DLU
MSDS
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Source Yeast
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Code CSB-EP853321DLU
MSDS
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Source E.coli
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Code CSB-EP853321DLU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP853321DLU
MSDS
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Source Baculovirus
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Code CSB-MP853321DLU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
cav
Uniprot No.
Alternative Names
cav; anon; fe; 1G5; anon1G5; Hoap; IG5; CG6219; Telomere-binding protein cav; Anonymous fast evolving 1G5; HP1/ORC-associated protein; HOAP p55; Protein caravaggio
Species
Drosophila melanogaster (Fruit fly)
Expression Region
1-345
Target Protein Sequence
MLLLLCVNMS GTQMSAFLRK YLADEDKKIR AQFKESDPNN KLILWMHEKT RITEEDLARP YTEDEVKELC LRTKVKVDMT AWNCLWEAKK RFEAKGRFVN KSERFINRMY MKAVRRKMVQ PYPEEFVAQR REIVAAETKK QNISRLDRWQ KKKSQNLSAP ESSPDAHASS NDAVQSHEDQ ANTNLSSLSQ MNFQVEAMAP PGVSSSDLSG IGDDEDEQQQ SGFQDENINR PETEINENSV RCDPINLGRM RTGCINSQAN NSFRNTESDP DYYMFGTQLS TLVRPTSTQE PDDQVNCPET EMNESWVRCD QINSESLSIG PSIDSEGTIT FQNTESEPID VTSIA
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Binds to chromosome ends in a sequence-dependent manner and is required for telomere capping.
Gene References into Functions
  1. genetic and biochemical assays indicate a repressing activity for HOAP PMID: 21695246
  2. HOAP has a role in functional centric heterochromatin PMID: 12826664
  3. HOAP-depleted telomeres activate both the DNA-damage response and the spindle assembly checkpoint. PMID: 18246067
  4. Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection PMID: 19181850
  5. HOAP interacts with Umbrea with functional role in mediating normal telomere behaviour in Drosophila PMID: 19190990

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Subcellular Location
Nucleus. Chromosome, telomere.
Database Links

KEGG: dme:Dmel_CG6219

STRING: 7227.FBpp0083943

UniGene: Dm.20244

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