CBK1 Antibody

1. Cbk1 and Bck2 are required for Mpk1 activation during heat shock and cell wall stress and for Mpk1 dephosphorylation during heat shock adaptation. PMID: 22031291
2. propose that Cdc14 coordinates cell separation with mitotic exit via FEAR-initiated phosphorylation of the Cbk1 HM site and MEN-activated reversal of mitotic CDK phosphorylations that block both Cbk1 and Ace2 function PMID: 21135117
3. Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control. PMID: 19962308
4. Mutations in BRR1 or MPT5 lead to a restoration of fertility induced by cbk1p mutation, and a more-or-less pronounced restoration of polarity; they also show genetic interactions with SSD1. PMID: 19546315
5. CBK1-S745F allele leads to a constitutively active form of Cbk1p that is independent of the upstream RAM network. PMID: 19967545
6. Phosphoregulation of Cbk1 is critical for RAM network function. Intramolecular autophosphorylation of the enzyme's activation loop is critical for kinase activity but is only partially required for cell separation and polarized growth. PMID: 17145962
7. Cbk1 exhibits a novel specificity that is likely conserved among related kinases from yeast to metazoans. Cbk1 is functionally restricted to the daughter cell, and cannot diffuse from the daughter to the mother. PMID: 18715118
8. These data suggest that an important function for Cbk1 and the RAM signaling network is to regulate growth and secretion via Golgi and Sec2/Sec4-dependent processes. PMID: 18843045

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KEGG: sce:YNL161W

STRING: 4932.YNL161W