cdk-1 Antibody

Code CSB-PA333911XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cdk-1 Polyclonal antibody
Uniprot No.
Target Names
cdk-1
Alternative Names
cdk-1 antibody; ncc-1 antibody; T05G5.3 antibody; Cyclin-dependent kinase 1 antibody; CDK1 antibody; EC 2.7.11.22 antibody; EC 2.7.11.23 antibody; Cell division control protein 2 homolog antibody; Cell division protein kinase 1 antibody; p34 protein kinase antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cdk-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Gene References into Functions
  1. CDK-1 regulates PLK-1 activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 activator SPAT-1 PMID: 26038951
  2. CDK-1 blocks rotation by inhibiting dynein association with microtubules. PMID: 21690306
  3. Use of loss- and gain-of-function genetic approaches demonstrates that CYY-1, a cyclin box-containing protein, drives synapse removal in this process. PMID: 21609829
  4. NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos PMID: 20053678
  5. Co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes. PMID: 16421191
  6. MBK-2 is activated during oocyte maturation by CDK-1-dependent phosphorylation of serine 68, a residue outside of the kinase domain required for full activity in vivo. PMID: 19879842

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Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links

KEGG: cel:CELE_T05G5.3

STRING: 6239.T05G5.3.2

UniGene: Cel.23379

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