Cdk5 Antibody

Code CSB-PA151943XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Cdk5 Polyclonal antibody
Uniprot No.
Target Names
Cdk5
Alternative Names
Cdk5 antibody; CG8203Cyclin-dependent kinase 5 homolog antibody; EC 2.7.11.22 antibody; Cell division protein kinase 5 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Cdk5 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development.
Gene References into Functions
  1. These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila mushroom body. PMID: 26394609
  2. The CDK5 phosphorylates MEKK1, and together, they activate the JNK pathway for apoptosis. PMID: 22388889
  3. The data of this study demonstrated that Cdk5/p35 kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila. PMID: 21775591
  4. Therefore, we propose that Abl and p35/p25 cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration. PMID: 16932754
  5. Cdk5/p35 did not have major effects on tau toxicity or phosphorylation. PMID: 18930955
  6. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration. PMID: 19263480

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Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Tissue Specificity
Abundantly expressed in all adult tissues. Lower levels found in larvae and early embryos. Barely detectable in late embryos.
Database Links

KEGG: dme:Dmel_CG8203

STRING: 7227.FBpp0086483

UniGene: Dm.640

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