CFAP53 Antibody

Code CSB-PA856981XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CFAP53 Polyclonal antibody
Uniprot No.
Target Names
CFAP53
Alternative Names
4933415I03Rik antibody; CCD11_HUMAN antibody; CCDC11 antibody; Cilia and flagella associated protein 53 antibody; Coiled coil domain containing 11 antibody; Coiled coil domain containing protein 11 antibody; Coiled-coil domain-containing protein 11 antibody; FLJ32743 antibody; HTX6 antibody; MGC117752 antibody; RGD1306734 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) CFAP53 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.
Gene References into Functions
  1. CCDC11 is a cilium-associated gene with a role in left-right patterning in Xenopus and in laterality disorders in humans PMID: 28621423
  2. Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish. PMID: 26531781
  3. CCDC11 has a conserved essential function in cilia of the vertebrate left-right organizer during embryogenesis. PMID: 25504577
  4. The authors suggest that CCDC11 is associated with autosomal recessive laterality defects of diverse phenotype resulting in SIT in one individual family member who is otherwise healthy, and in complex laterality anomalies (HS) in another member. PMID: 22577226
Involvement in disease
Heterotaxy, visceral, 6, autosomal (HTX6)
Subcellular Location
Cell projection, cilium.
Protein Families
CFAP53 family
Tissue Specificity
Expressed in skin fibroblasts (at protein level).
Database Links

HGNC: 26530

OMIM: 614759

KEGG: hsa:220136

STRING: 9606.ENSP00000381553

UniGene: Hs.658630

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