Recombinant Human Coiled-coil domain-containing protein 11 (CCDC11)

Code CSB-YP856981HU
MSDS
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Source Yeast
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Code CSB-EP856981HU
MSDS
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Source E.coli
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Code CSB-EP856981HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP856981HU
MSDS
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Source Baculovirus
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Code CSB-MP856981HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CFAP53
Uniprot No.
Alternative Names
4933415I03Rik; CCD11_HUMAN; CCDC11; Cilia and flagella associated protein 53; Coiled coil domain containing 11; Coiled coil domain containing protein 11; Coiled-coil domain-containing protein 11; FLJ32743; HTX6; MGC117752; RGD1306734
Species
Homo sapiens (Human)
Expression Region
1-514
Target Protein Sequence
MYSQRFGTVQ REVKGPTPKV VIVRSKPPKG QGAEHHLERI RRSHQKHNAI LASIKSSERD RLKAEWDQHN DCKILDSLVR ARIKDAVQGF IINIEERRNK LRELLALEEN EYFTEMQLKK ETIEEKKDRM REKTKLLKEK NEKERQDFVA EKLDQQFRER CEELRVELLS IHQKKVCEER KAQIAFNEEL SRQKLVEEQM FSKLWEEDRL AKEKREAQEA RRQKELMENT RLGLNAQITS IKAQRQATQL LKEEEARLVE SNNAQIKHEN EQDMLKKQKA KQETRTILQK ALQERIEHIQ QEYRDEQDLN MKLVQRALQD LQEEADKKKQ KREDMIREQK IYHKYLAQRR EEEKAQEKEF DRILEEDKAK KLAEKDKELR LEKEARRQLV DEVMCTRKLQ VQEKLQREAK EQEERAMEQK HINESLKELN CEEKENFARR QRLAQEYRKQ LQMQIAYQQQ SQEAEKEEKR REFEAGVAAN KMCLDKVQEV LSTHQVLPQN IHPMRKACPS KLPP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.
Gene References into Functions
  1. CCDC11 is a cilium-associated gene with a role in left-right patterning in Xenopus and in laterality disorders in humans PMID: 28621423
  2. Cfap53 is a conserved regulator of organ laterality in both humans and zebrafish. PMID: 26531781
  3. CCDC11 has a conserved essential function in cilia of the vertebrate left-right organizer during embryogenesis. PMID: 25504577
  4. The authors suggest that CCDC11 is associated with autosomal recessive laterality defects of diverse phenotype resulting in SIT in one individual family member who is otherwise healthy, and in complex laterality anomalies (HS) in another member. PMID: 22577226
Involvement in disease
Heterotaxy, visceral, 6, autosomal (HTX6)
Subcellular Location
Cell projection, cilium.
Protein Families
CFAP53 family
Tissue Specificity
Expressed in skin fibroblasts (at protein level).
Database Links

HGNC: 26530

OMIM: 614759

KEGG: hsa:220136

STRING: 9606.ENSP00000381553

UniGene: Hs.658630

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