CLN3 Antibody

1. G0/G1 transition, via Rim 15 and CLN3, might govern the fermentation rate of bottom-fermenting brewer's yeast in high-gravity wort. PMID: 27212268
2. Whi5 phosphorylation by Cln3-Cdk1 embedded in the G1/S network dynamically controls critical cell size and cell fate. PMID: 27094800
3. In CLN3, Whi3 may bind to the 3' GCAU motifs to attract the Ccr4-Not complex to promote RNA deadenylation and turnover, and Whi3 may bind to the 5' GCAU motifs to inhibit translation. PMID: 24386402
4. T36 phosphorylation triggers displacement of Ydj1, allowing Ssa1 to bind the G1 cyclin Cln3 and promote its degradation; these results establish an active role for Hsp70 chaperones as signal transducers mediating growth control of G1 cyclin abundance and activity PMID: 23217712
5. The spatial regulation of GAL1 and CLN3 transcripts is what allows growth to be maintained during fluctuations of glucose availability. PMID: 22160690
6. Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1 PMID: 19823669
7. Cln3 must overcome Far1 to trigger Cln-Cdc28 activation, which then turns on transcription; a second threshold is required together with the Cln3/Far1 threshold for carbon source modulation of protein content per cell at the onset of DNA replication PMID: 15520229
8. HPD(hydrophobic patch domain) of Cln3 identified important for interaction of Cln3 with Cdc28. PMID: 16200502
9. Cln3 contains a chaperone-regulatory Ji domain that counteracts Ydj1, a J chaperone essential for ER release and nuclear accumulation of Cln3 in late G1. PMID: 17560371
10. Cln3 activates only G1/S phase genes PMID: 19158491

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KEGG: sce:YAL040C

STRING: 4932.YAL040C